Push-Pull Control of Motor Output

Inhibition usually decreases input–output excitability of neurons. If, however, inhibition is coupled to excitation in a push–pull fashion, where inhibition decreases as excitation increases, neuron excitability can be increased. Although the presence of push–pull organization has been demonstrated in single cells, its functional impact on neural processing depends on its effect on the system level. We studied push–pull in the motor output stage of the feline spinal cord, a system that allows independent control of inhibitory and excitatory components. Push–pull organization was clearly present in ankle extensor motoneurons, producing increased peak-to-peak modulation of synaptic currents. The effect at the system level was equally strong. Independent control of the inhibitory component showed that the stronger the background of inhibition, the greater the peak force production. This illustrates the paradox at the heart of push–pull organization: increased force output can be achieved by increasing background inhibition to provide greater disinhibition

Local Starbursts in a Cosmological Context

In this contribution I introduce some of the major issues that motivate the conference, with an emphasis on how starbursts fit into the ``big picture''. I begin by defining starbursts in several different ways, and discuss the merits and limitations of these definitions. I will argue that the most physically useful definition of a starburst is its ``intensity'' (star formation rate per unit area). This is the most natural parameter to compare local starbursts with physically similar galaxies at high redshift, and indeed I will argue that local starbursts are unique laboratories to study the processes at work in the early universe. I will describe how NASA's GALEX mission has uncovered a rare population of close analogs to Lyman Break Galaxies in the local universe. I will then compare local starbursts to the Lyman-Break and sub-mm galaxies high redshift populations, and speculate that the multidimensional ``manifold'' of starbursts near and far can be understood largely in terms of the Schmidt/Kennicutt law and galaxy mass-metallicity relation. I will briefly summarize he properties of starburst-driven galactic superwinds and their possible implications for the evolution of galaxies and the IGM. These complex multiphase flows are best studied in nearby starbursts, where we can study the the hot X-ray gas that contains the bulk of the energy and newly produced metals.Comment: Proceedings of the Conference "Starbursts: Fropm 30 Doradus to Lyman Break Galaxies

Neuromodulation impact on nonlinear firing behavior of a reduced model motoneuron with the active dendrite

Neuromodulatory inputs from brainstem systems modulate the normal function of spinal motoneurons by altering the activation properties of persistent inward currents (PICs) in their dendrites. However, the effect of the PIC on firing outputs also depends on its location in the dendritic tree. To investigate the interaction between PIC neuromodulation and PIC location dependence, we used a two-compartment model that was biologically realistic in that it retains directional and frequency-dependent electrical coupling between the soma and the dendrites, as seen in multi-compartment models based on full anatomical reconstructions of motoneurons. Our two-compartment approach allowed us to systematically vary the coupling parameters between the soma and the dendrite to accurately reproduce the effect of location of the dendritic PIC on the generation of nonlinear (hysteretic) motoneuron firing patterns. Our results show that as a single parameter value for PIC activation was either increased or decreased by 20% from its default value, the solution space of the coupling parameter values for nonlinear firing outputs was drastically reduced by approximately 80%. As a result, the model tended to fire only in a linear mode at the majority of dendritic PIC sites. The same results were obtained when all parameters for the PIC activation simultaneously changed only by approximately ±10%. Our results suggest the democratization effect of neuromodulation: the neuromodulation by the brainstem systems may play a role in switching the motoneurons with PICs at different dendritic locations to a similar mode of firing by reducing the effect of the dendritic location of PICs on the firing behavior

The Footprint of F-theory at the LHC

Recent work has shown that compactifications of F-theory provide a potentially attractive phenomenological scenario. The low energy characteristics of F-theory GUTs consist of a deformation away from a minimal gauge mediation scenario with a high messenger scale. The soft scalar masses of the theory are all shifted by a stringy effect which survives to low energies. This effect can range from 0 GeV up to ~ 500 GeV. In this paper we study potential collider signatures of F-theory GUTs, focussing in particular on ways to distinguish this class of models from other theories with an MSSM spectrum. To accomplish this, we have adapted the general footprint method developed recently for distinguishing broad classes of string vacua to the specific case of F-theory GUTs. We show that with only 5 fb^(-1) of simulated LHC data, it is possible to distinguish many mSUGRA models and low messenger scale gauge mediation models from F-theory GUTs. Moreover, we find that at 5 fb^(-1), the stringy deformation away from minimal gauge mediation produces observable consequences which can also be detected to a level of order ~ +/- 80 GeV. In this way, it is possible to distinguish between models with a large and small stringy deformation. At 50 fb^(-1), this improves to ~ +/- 10 GeV.Comment: 85 pages, 37 figure

T-Branes and Monodromy

We introduce T-branes, or "triangular branes," which are novel non-abelian bound states of branes characterized by the condition that on some loci, their matrix of normal deformations, or Higgs field, is upper triangular. These configurations refine the notion of monodromic branes which have recently played a key role in F-theory phenomenology. We show how localized matter living on complex codimension one subspaces emerge, and explain how to compute their Yukawa couplings, which are localized in complex codimension two. Not only do T-branes clarify what is meant by brane monodromy, they also open up a vast array of new possibilities both for phenomenological constructions and for purely theoretical applications. We show that for a general T-brane, the eigenvalues of the Higgs field can fail to capture the spectrum of localized modes. In particular, this provides a method for evading some constraints on F-theory GUTs which have assumed that the spectral equation for the Higgs field completely determines a local model.Comment: 110 pages, 5 figure

Equality of opportunity and educational achievement in Portugal

Portugal has one of the highest levels of income inequality in Europe, and low wages and unemployment are concentrated among low skill individuals. Education is an important determinant of inequality. However, there are large differences in the educational attainment of different individuals in the population, and the sources of these differences emerge early in the life-cycle when families play a central role in individual development. We estimate that most of the variance of school achievement at age 15 is explained by family characteristics. Observed school inputs explain very little of adolescent performance. Children from highly educated parents benefit of rich cultural environments in the home and become highly educated adults. Education policy needs to be innovative: (1) it needs to explicitly recognize the fundamental long run role of families on child development; (2) it needs to acknowledge the failure of traditional input based policies